Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Sep;11(3):177-84.
doi: 10.1016/j.prrv.2010.05.003. Epub 2010 Jun 16.

Early eradication of Pseudomonas aeruginosa in patients with cystic fibrosis

Bridget Stuart  1 , Jenny H Lin, Peter J Mogayzel Jr
Affiliations
Review

Early eradication of Pseudomonas aeruginosa in patients with cystic fibrosis

Bridget Stuart et al. Paediatr Respir Rev. 2010 Sep.

Abstract

Pseudomonas aeruginosa (Pa) is the predominant organism infecting the airways of patients with cystic fibrosis (CF). This organism has an armamentarium of survival mechanisms that allows it to survive in the CF airway. Since colonization and chronic infection with Pa is associated with poorer lung function and increased morbidity and mortality, therapies that can prevent infection could significantly improve the lives of patients with CF. Numerous studies have examined the effects of treatment on the eradication of Pa as a means to ameliorate disease. This article outlines the pathophysiology and clinical implication of Pa acquisition, and reviews the existing treatment regimens aimed at early eradication of Pa in patients with CF.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Illustration of the time course of Pseudomonas aeruginosa infection in patients with cystic fibrosis using Leeds definition of infection and colonization. Taken with permission from Lee.
See this image and copyright information in PMC

References

    1. Andersen DH. Cystic fibrosis of the pancreas and its relationship to celiac disease: a clinical and pathological study. Am J Dis Child. 1938;56:344.
    1. Kerem B, Rommens JM, Buchanan JA, et al. Identification of the cystic fibrosis gene: genetic analysis. Science. 1989;245(4922):1073–1080. - PubMed
    1. Lee TW. Eradication of early Pseudomonas infection in cystic fibrosis. Chron Respir Dis. 2009;6(2):99–107. - PubMed
    1. Matsui H, Grubb BR, Tarran R, et al. Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease. Cell. 1998;95(7):1005–1015. - PubMed
    1. Sagel SD, Sontag MK, Accurso FJ. Relationship between antimicrobial proteins and airway inflammation and infection in cystic fibrosis. Pediatr Pulmonol. 2009;44(4):402–409. - PubMed