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. 2010 Oct;203(4):366.e1-6.
doi: 10.1016/j.ajog.2010.06.036. Epub 2010 Aug 8.

Plasma 25-hydroxyvitamin D levels in early-onset severe preeclampsia

Christopher J Robinson  1 , Mark C Alanis, Carol L Wagner, Bruce W Hollis, Donna D Johnson
Affiliations

Plasma 25-hydroxyvitamin D levels in early-onset severe preeclampsia

Christopher J Robinson et al. Am J Obstet Gynecol. 2010 Oct.

Abstract

Objective: Vitamin D deficiency has been linked to adverse pregnancy outcomes. The purpose of this investigation was to assess total 25-hydroxyvitamin D (25-OH-D) levels at diagnosis of early-onset severe preeclampsia (EOSPE).

Study design: After institutional review board approval, we enrolled subjects with EOSPE (<34 weeks' gestation with severe preeclampsia) in this case-control investigation in a 1:2 ratio with gestation-matched, contemporaneous control subjects. Demographic and outcome information was collected for each subject. Plasma total 25-OH-D levels were determined by radioimmunoassay and reported in nanograms per milliliter. Results were analyzed by Mann-Whitney U and multivariable regression.

Results: Subjects with EOSPE (n = 50) were noted to have decreased total 25-OH-D levels relative to healthy control subjects (n = 100; P < .001). This difference in total 25-OH-D remained significant after control for potential confounders.

Conclusion: Total 25-OH-D is decreased at diagnosis of EOSPE. Further study is needed to understand the impact of vitamin D deficiency on pregnancy outcomes.

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Figures

Figure 1
Figure 1. Maternal Plasma 25-OH-D in EOSPE verses Controls
Patients with EOSPE had significantly decreased levels of 25-OH-D relative to healthy control pregnancies matched for gestational age at plasma sampling (median 25-OH-D 18 ng/mL vs. 32 ng/mL; p<0.001). P value was determined by Mann Whitney U test.
Figure 2
Figure 2. Plasma 25-OH-D by Race and EOSPE Status
African American and Caucasian women with EOSPE were noted to have decreased plasma levels of 25-OH-D relative to matched race, control pregnancies. African American women were noted to have the lowest plasma 25-OH-D levels when compared to Caucasian women. Bars represent mean 25-OH-D levels (mean±SEM). (P values determined using Tukey-Kramer test).
See this image and copyright information in PMC

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