Review
doi: 10.1016/j.jgyn.2010.06.010.
Epub 2010 Aug 7.
[Contributions of the ex vivo human perfused placenta in the study of placental transfer of drugs]
[Article in
French]
Affiliations
- PMID: 20692775
- DOI: 10.1016/j.jgyn.2010.06.010
Item in Clipboard
Review
[Contributions of the ex vivo human perfused placenta in the study of placental transfer of drugs]
[Article in
French]
J Gynecol Obstet Biol Reprod (Paris).
2010 Dec.
Free article
Abstract
Perfused human placental lobule was developed during the 1970s. Only this model respects the anatomical features of the human placenta. This approach allows different technical conditions (concentrations of drugs…) without ethical problems. Limitations of this ex vivo model are detailed in this review, also its recent contributions in better understanding of placental passage of drugs.
Copyright © 2010 Elsevier Masson SAS. All rights reserved.
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