[Development and clinical pathology of carcinoma of the gallbladder and extrahepatic bile duct]

Abstract

We reported the causes of cancer development and clinical pathology of the gallbladder and extrahepatic bile duct carcinoma. Gallstone, secondary bile acid, and congenital malunion between the bile duct and the pancreatic duct are considered as causes of intestinal metaplasia of the mucosa of the biliary tract. The intestinal metaplasia has closely relationship with development of dysplasia and carcinoma. We treated 101 patients with gallbladder carcinoma and 85 patients with bile duct carcinoma. Sex ratios of the patients with gallbladder carcinoma and bile duct carcinoma were 1:1.8 and 1.7:1. Fifty-one of 101 patients with gallbladder carcinoma had gallstones, and 17 of them had congenital malunion between the bile duct and the pancreatic duct. In four of 23 patients with gallbladder carcinoma and 10 of 64 patients with bile duct carcinoma, superficial cancer spread was seen and it was very important for surgical operation clinically.