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. 2010 Sep;42(9):739-741.
doi: 10.1038/ng.639. Epub 2010 Aug 8.

Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2

Thorsten Thye #  1   2 , Fredrik O Vannberg #  3 , Sunny H Wong  3 , Ellis Owusu-Dabo  4   5 , Ivy Osei  6 , John Gyapong  6 , Giorgio Sirugo  7 , Fatou Sisay-Joof  7 , Anthony Enimil  4   8 , Margaret A Chinbuah  6 , Sian Floyd  9 , David K Warndorff  10 , Lifted Sichali  10 , Simon Malema  10 , Amelia C Crampin  9 , Bagrey Ngwira  10 , Yik Y Teo  3 , Kerrin Small  3 , Kirk Rockett  3 , Dominic Kwiatkowski  3 , Paul E Fine  9   10 , Philip C Hill  7 , Melanie Newport  7 , Christian Lienhardt  7 , Richard A Adegbola  7 , Tumani Corrah  7 , Andreas Ziegler  2 ; African TB Genetics Consortium; Wellcome Trust Case Control Consortium; Andrew P Morris  3 , Christian G Meyer  1 , Rolf D Horstmann #  1 , Adrian V S Hill #  3
Affiliations

Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2

Thorsten Thye et al. Nat Genet. 2010 Sep.

Erratum in

  • Nat Genet. 2011 Oct;43(10):1040

Abstract

We combined two tuberculosis genome-wide association studies from Ghana and The Gambia with subsequent replication in a combined 11,425 individuals. rs4331426, located in a gene-poor region on chromosome 18q11.2, was associated with disease (combined P = 6.8 x 10(-9), odds ratio = 1.19, 95% CI = 1.13-1.27). Our study demonstrates that genome-wide association studies can identify new susceptibility loci for infectious diseases, even in African populations, in which levels of linkage disequilibrium are particularly low.

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Figures

Figure 1
Figure 1
Association plot with fine mapping markers on chromosome 18 in the combined analysis (r2 values between rs4331426 and adjacent SNPs derived from the Ghanaian population; P uncorrected for λGC).
See this image and copyright information in PMC

Comment in

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