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. 1991 May;20(4):497-504.
doi: 10.1007/BF01065838.

The induction of cytochrome P-450-IA1 in juvenile fish by creosote-contaminated sediment

W P Schoor  1 , D E Williams, N Takahashi
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The induction of cytochrome P-450-IA1 in juvenile fish by creosote-contaminated sediment

W P Schoor et al. Arch Environ Contam Toxicol. 1991 May.

Abstract

Intact sediment cores, including their surface layers, were used in simulated field exposure tests of juvenile guppies (Poecilia reticulata) to creosote-contaminated sediments. Mixed-function oxygenase activity was induced in the fish after 43 days of exposure to environmentally realistic, sublethal concentrations of creosote-related compounds. An average 50-fold induction in the cytochrome P-450-IA1 was found in the liver in the absence of any histopathological lesions. The possibility that a threshold level for proliferative liver changes was not reached is discussed in the light of the observed biochemical activation.

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