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. 1991 Jul 15;178(1):242-7.
doi: 10.1016/0006-291x(91)91805-m.

Occurrence of cholesterol 7 alpha- and 7 beta-hydroperoxides in rat skin as aging markers

N Ozawa  1 , S Yamazaki, K Chiba, H Aoyama, H Tomisawa, M Tateishi, T Watabe
Affiliations

Occurrence of cholesterol 7 alpha- and 7 beta-hydroperoxides in rat skin as aging markers

N Ozawa et al. Biochem Biophys Res Commun. .

Abstract

Evidence for presence of cholesterol 7 alpha- and 7 beta-hydroperoxides in rat skin was presented for the first time. The 7-hydroperoxides in rat skin were reduced with sodium borohydride and trimethylsilylated for identification with the authentic compounds by gas chromatography/mass spectrometry. A content of cholesterol 7-hydroperoxides in rat skin, determined by high performance liquid chromatography with a chemiluminescence detector, highly correlated with the age of rats (r = 0.874; between 1 and 45 weeks old), indicating that cholesterol 7 alpha- and 7 beta-hydroperoxides were good markers for aging.

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