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. 2010 Aug;12(8):597-602.
doi: 10.1111/j.1751-7176.2010.00306.x.

Urine albumin excretion, within normal range, reflects increasing prevalence of metabolic syndrome in patients with essential hypertension

Gregory Vyssoulis  1 , Eva Karpanou, Pangiotis Spanos, Stella-Maria Kyvelou, Dionysios Adamopoulos, Christodoulos Stefanadis
Affiliations

Urine albumin excretion, within normal range, reflects increasing prevalence of metabolic syndrome in patients with essential hypertension

Gregory Vyssoulis et al. J Clin Hypertens (Greenwich). 2010 Aug.

Abstract

Microalbuminuria is a prognostic marker of cardiovascular disease and is related to metabolic syndrome (MetS). For this purpose, the authors examined the relationship of low grade albuminuria to MetS, using 4 current definitions and a MetS score. They studied 6650 consecutive, nondiabetic, hypertensive patients with normal microalbumin excretion. MetS was defined by Adult Treatment Panel III, American Heart Association, World Heart Organization, International Diabetes Federation criteria, and MetS Gruppo Italiano per lo Studio della Streptochinasi nell'Infarcto Miocardico (GISSI) score. Urine microalbumin concentration was measured after a 24-hour urine collection by immunonephelometry. By all definitions, hypertensive patients with MetS had higher microalbumin levels. Significantly higher microalbumin levels were observed as the number of metabolic components rose. After adjustment for systolic blood pressure, the strength of this association was reduced to a nonsignificant level. Microalbumin levels, within normal range, are increased in patients with MetS, irrespective of the definition criteria.

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Figure
Different distributions of albumin quartiles according to the number of metabolic syndrome components.
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