A custody battle for the mind: evidence for extensive imprinting in the brain
- PMID: 20696374
- DOI: 10.1016/j.neuron.2010.07.026
A custody battle for the mind: evidence for extensive imprinting in the brain
Abstract
Relatively few genes (approximately 100) have previously been shown to be imprinted such that their expression in progeny derives from either the maternal or paternal copy. Two recent studies by Gregg et al. (2010a, 2010b) in Science expand this list by an order of magnitude, revealing complex patterns of parent-of-origin bias in gene expression in the brain that are developmentally and regionally restricted, and in many cases, sexually dimorphic.
(c) 2010 Elsevier Inc. All rights reserved.
Comment on
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High-resolution analysis of parent-of-origin allelic expression in the mouse brain.Science. 2010 Aug 6;329(5992):643-8. doi: 10.1126/science.1190830. Epub 2010 Jul 8. Science. 2010. PMID: 20616232 Free PMC article.
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Sex-specific parent-of-origin allelic expression in the mouse brain.Science. 2010 Aug 6;329(5992):682-5. doi: 10.1126/science.1190831. Epub 2010 Jul 8. Science. 2010. PMID: 20616234 Free PMC article.
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