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Comment
. 2010 Aug 11;18(8):891-2.
doi: 10.1016/j.str.2010.07.004.

Further insights into the ubiquitin pathway: understanding the scarlet letter code

Annalisa Pastore  1
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Further insights into the ubiquitin pathway: understanding the scarlet letter code

Annalisa Pastore. Structure. .
Free article

Abstract

Understanding the machinery that decides proteins' fate by tagging them with ubiquitin is an important goal of structural biology. Benirschke et al. (2010) have solved the structure of human E4B (or UFD2a), a U-box-containing protein that functions both as an E3 Ub ligase and as an E4 polyUb chain elongation factor.

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