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Comparative Study
. 2010 Aug 10;75(6):508-12.
doi: 10.1212/WNL.0b013e3181eccfcd.

Analysis of GWAS-linked loci in Parkinson disease reaffirms PARK16 as a susceptibility locus

E-K Tan  1 , H-H Kwok, L C Tan, W-T Zhao, K M Prakash, W-L Au, R Pavanni, Y-Y Ng, W Satake, Y Zhao, T Toda, J-J Liu
Affiliations
Comparative Study

Analysis of GWAS-linked loci in Parkinson disease reaffirms PARK16 as a susceptibility locus

E-K Tan et al. Neurology. .

Erratum in

  • Neurology. 2010 Oct 12;75(15):1399. Kwok, H-K [corrected to Kwok, H-H]

Abstract

Objective: A genome-wide association study (GWAS) in the Japanese population identified 2 new Parkinson disease (PD) susceptibility loci on 1q32 (PARK16) (OMIM 613164) and BST1. We analyzed single nucleotide polymorphism (SNPs) located at the GWAS-linked loci (PARK16, PARK8, PARK1, and BST1) in a Chinese population and also conducted a meta-analysis in Asians by pooling 2 independent replication studies from Japan.

Methods: We conducted an analysis of 13 SNPs associated with PD GWAS-linked loci in 2 case-control cohorts comprised of 1,349 ethnic Chinese subjects.

Results: PARK16, PARK8, and PARK1 loci but not BST1 were found to be associated with PD. PARK16 SNPs were associated with a decreased risk while PARK1 and PARK8 SNPs were associated with an increased risk of PD. A pooled analysis of our Chinese cohorts and 2 Japanese replication cohorts involving 1,366 subjects with PD and 16,669 controls revealed robust association with these 3 loci and also BST1. There was a trend toward a stronger protective effect of SNPs at the PARK16 locus in sporadic PD compared to familial cases and in older compared to younger subjects.

Conclusions: Our study reaffirms the role of GWAS-linked loci in PD in Asian subjects and the strength of association is similar between Chinese and Japanese subjects. Efforts to elucidate the associated gene within PARK16 locus are warranted.

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Figures

None
Figure Selection of genome-wide association study single nucleotide polymorphisms (SNPs) Only 1 SNP from each shaded box was selected for analysis as the 2 SNPs in each shaded box are in close linkage disequilibrium (r2 >0.8).
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