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Case Reports
. 2010 Sep-Oct;30(5):404-7.
doi: 10.4103/0256-4947.67087.

Evolution of tigecycline resistance in Klebsiella pneumoniae in a single patient

Nada S Al-Qadheeb  1 , Sahar Althawadi, Abdulaziz Alkhalaf, Suleiman Hosaini, Abdulrahman A Alrajhi
Affiliations
Case Reports

Evolution of tigecycline resistance in Klebsiella pneumoniae in a single patient

Nada S Al-Qadheeb et al. Ann Saudi Med. 2010 Sep-Oct.

Abstract

Carbapenemase-producing Klebsiella pneumoniae infections carry serious clinical and infection-control implications. Isolates possessing such hydrolyzing enzymes have been described in the United States and around the world. Besides being resistant to carbapenems, they usually confer resistance to fluoroquinolones, piperacillin-tazobactam, and extended-spectrum cephalosporins. Tigecycline demonstrates in vitro activity against these organisms, but reported resistance raises concern about tigecycline use for these infections. We describe a carbapenemase-producing K pneumoniae evolving resistance to tigecycline in a 75-year-old male after a prolonged stay in a critical care unit.

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Figures

Figure 1
Figure 1
Pulsed-field gel electrophoresis of the three isolates of K pneumoniae. Computer analysis of Xbal digested K pneumoniae isolates, using BioNumerics software (Applied Maths).
See this image and copyright information in PMC

References

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