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Review
. 1991 Apr;3(2):186-92.
doi: 10.1016/0952-7915(91)90048-6.

Molecular and cellular aspects of early B-cell development

Affiliations
Review

Molecular and cellular aspects of early B-cell development

T Tsubata et al. Curr Opin Immunol. 1991 Apr.

Abstract

The molecular mechanisms underlying pre-B cell growth and immunoglobulin gene rearrangement have been actively investigated. Some growth factors for B-cell precursors as well as some genes activating V(D)J recombination have been identified. Furthermore, the molecular structure and signaling capacity of the surface immunoglobulin of pre-B cells have been characterized.

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