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Comparative Study
. 2010 Oct;117(10):1167-70.
doi: 10.1007/s00702-010-0456-x. Epub 2010 Aug 10.

Cerebrospinal fluid insulin during non-neurological surgery

Sara Bromander  1 , Rolf Anckarsäter, Bo Ahrén, Marianne Kristiansson, Kaj Blennow, Agneta Holmäng, Henrik Zetterberg, Henrik Anckarsäter, Caroline E Wass
Affiliations
Comparative Study

Cerebrospinal fluid insulin during non-neurological surgery

Sara Bromander et al. J Neural Transm (Vienna). 2010 Oct.

Abstract

Insulin plays an important metabolic and transmitter role in the central nervous system, but few studies have investigated the relationship between central and peripheral insulin concentrations. 35 patients undergoing knee surgery had cerebrospinal fluid (CSF) samples drawn before, 3 h after, and in the morning following surgery. Serum insulin concentrations increased after surgery and CSF insulin concentrations changed in the same direction with far smaller amplitude. These results indicate that the blood-brain barrier protects the brain from stress-induced peripheral hormonal fluctuations.

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References

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