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Case Reports
. 2011 Jan;26(1):95-7.
doi: 10.1007/s11606-010-1466-y. Epub 2010 Aug 10.

Fulminant, non-antibiotic associated Clostridium difficile colitis following Salmonella gastroenteritis

Stephanie A C Halvorson  1 , Andrea S Cedfeldt, Alan J Hunter
Affiliations
Case Reports

Fulminant, non-antibiotic associated Clostridium difficile colitis following Salmonella gastroenteritis

Stephanie A C Halvorson et al. J Gen Intern Med. 2011 Jan.

Abstract

In the last decade there has been increasing awareness of the virulence and changing epidemiology of Clostridium difficile (C. difficile). While the vast majority of clinical cases of C. difficile are associated with antimicrobial or nosocomial exposure, this syndrome has been well described in the absence of antibiotic use. We present an unusual case of fatal, non-antibiotic associated C. difficile colitis following Salmonella serotype Saintpaul gastroenteritis in a previously healthy young person. We review the typical risk factors for C. difficile colitis and fulminant disease. We also review the epidemiology of community-acquired C. difficile-associated disease (CA-CDAD) and highlight Salmonella infection as a potential risk factor for development of CA-CDAD.

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Figures

Figure 1
Figure 1
Radiographic “thumbprinting” (wide transverse bands associated with haustral fold thickening).
Figure 2
Figure 2
Gross specimen showing extensive pseudomembranes on the colonic mucosa.
See this image and copyright information in PMC

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