[Mast cells and heparin--key links in adaptive and pathological processes]

Abstract

Participation of mast cells and heparin in adaptive and pathological processes is discussed with special reference to heparin pool in mast cell granules. Hypotheses explaining conversion of normal mast cells to phenotypically pathologic ones are analysed. Prospects for enhancement of adaptive abilities of the organism and approaches to the treatment of diseased organs are discussed in terms of protection and restoration of heparin cells in the mast cells.