Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1991 Jun;63(6):901-4.
doi: 10.1038/bjc.1991.198.

Monitoring therapeutic response to tamoxifen in NMU-induced rat mammary tumours by 31P MRS

S Baluch  1 , C J Midwood, J R Griffiths, M Stubbs, R C Coombes
Affiliations
Free PMC article

Monitoring therapeutic response to tamoxifen in NMU-induced rat mammary tumours by 31P MRS

S Baluch et al. Br J Cancer. 1991 Jun.
Free PMC article

Abstract

Tamoxifen injections were given once a week for 4 weeks to 19 rats bearing N-methyl-N-nitrosourea (NMU)-induced mammary carcinomas. NMR spectra were collected on days 2, 7, 14, 21 and 28. Only 42% of the tumours responded to the tamoxifen in that they regressed significantly; another 21% did not change in size and 37% grew significantly. In the ones that did subsequently regress there were significant changes in the NTP/Pi ratio as early as 2 days after treatment, before any detectable change in volume was recorded, and continuing up to 21 days. The significance of these findings and the possible mechanisms underlying the changes are discussed.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Proc Natl Acad Sci U S A. 1983 Jan;80(2):334-8 - PubMed
    1. Cancer Res. 1987 Jul 1;47(13):3496-503 - PubMed
    1. Magn Reson Med. 1984 Dec;1(4):508-34 - PubMed
    1. Cancer Res. 1988 Jan 1;48(1):89-93 - PubMed
    1. Cancer Res. 1988 Feb 1;48(3):676-81 - PubMed

Publication types