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Review
. 2010 Sep 7;103(6):759-64.
doi: 10.1038/sj.bjc.6605845. Epub 2010 Aug 10.

Neoadjuvant endocrine therapy in primary breast cancer: indications and use as a research tool

Y H Chia  1 , M J Ellis, C X Ma
Affiliations
Review

Neoadjuvant endocrine therapy in primary breast cancer: indications and use as a research tool

Y H Chia et al. Br J Cancer. .

Abstract

Neoadjuvant endocrine therapy has been increasingly employed in clinical practice to improve surgical options for postmenopausal women with bulky hormone receptor-positive breast cancer. Recent studies indicate that tumour response in this setting may predict long-term outcome of patients on adjuvant endocrine therapy, which argues for its broader application in treating hormone receptor-positive disease. From the research perspective, neoadjuvant endocrine therapy provides a unique opportunity for studies of endocrine responsiveness and the development of novel therapeutic agents.

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Figure 1
Figure 1
Schema for ACOSOG trial Z1031 Cohort B.
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