Efficacy and tolerability of injectable sodium valproate in patients with mania
- PMID: 20703399
- PMCID: PMC2913561
- DOI: 10.4103/0019-5545.31603
Efficacy and tolerability of injectable sodium valproate in patients with mania
Abstract
Background: Sodium valproate is among the newer mood stabilizers and is also an anticonvulsant.
Aim: To assess the effect of intravenous sodium valproate in patients with acute manic episodes of bipolar disorder.
Methods: A 1-week open trial was conducted in the year 2004-2005 at the emergency ward of the Psychiatric Centre, SMS Medical College, Jaipur, in which 30 patients participated.
Conclusion: Substantial improvement was seen. No major side-effects were noted except marginal elevation of the SGOT and SGPT. The findings suggest that injectable sodium valproate is a safe and effective mood stabilizer for patients with mania.
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