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. 2010 Dec;40(3):248-57.
doi: 10.1007/s12160-010-9217-1.

Association of depression with antihypertensive medication adherence in older adults: cross-sectional and longitudinal findings from CoSMO

Marie Krousel-Wood  1 , Tareq Islam, Paul Muntner, Elizabeth Holt, Cara Joyce, Donald E Morisky, Larry S Webber, Edward D Frohlich
Affiliations

Association of depression with antihypertensive medication adherence in older adults: cross-sectional and longitudinal findings from CoSMO

Marie Krousel-Wood et al. Ann Behav Med. 2010 Dec.

Abstract

Background: Little is known about the associations between depressive symptoms, social support and antihypertensive medication adherence in older adults.

Purpose: We evaluated the cross-sectional and longitudinal associations between depressive symptoms, social support and antihypertensive medication adherence in a large cohort of older adults.

Methods: A cohort of 2,180 older adults with hypertension was administered questionnaires, which included the Center for Epidemiologic Studies-Depression Scale, the Medical Outcomes Study Social Support Index, and the hypertension-specific Morisky Medication Adherence Scale at baseline and 1 year later.

Results: Overall, 14.1% of participants had low medication adherence, 13.0% had depressive symptoms, and 33.9% had low social support. After multivariable adjustment, the odds ratios that participants with depressive symptoms and low social support would have low medication adherence were 1.96 (95% confidence interval (CI) 1.43, 2.70) and 1.27 (95% CI 0.98, 1.65), respectively, at baseline and 1.87 (95% CI 1.32, 2.66) and 1.30 (95% CI 0.98, 1.72), respectively, at 1 year follow-up.

Conclusion: Depressive symptoms may be an important modifiable barrier to antihypertensive medication adherence in older adults.

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Conflict of interest statement

Conflict of Interest Disclosure None.

Figures

Fig. 1
Fig. 1
Adjusted odds ratios of low antihypertensive medication adherence associated with the presence of depressive symptoms by demographics, Charlson comorbidity scores, and level of social support. Odds ratios were calculated using models that included age, gender, race, education, marital status, Charlson comorbidity score and social support; HS high school; p values for interactions across subgroups were not significant. Square represents odds ratio, line represents 95% confidence interval
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