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Review
. 2010 Nov;71(11):1061-6.
doi: 10.1016/j.humimm.2010.08.001. Epub 2010 Aug 10.

Myeloid-derived suppressor cells: natural regulators for transplant tolerance

Peter Boros  1 , Jordi C Ochando, Shu-Hsia Chen, Jonathan S Bromberg
Affiliations
Review

Myeloid-derived suppressor cells: natural regulators for transplant tolerance

Peter Boros et al. Hum Immunol. 2010 Nov.

Abstract

Myeloid derived suppressor cells (MDSC) contribute to the negative regulation of immune response in cancer patients. This review summarizes results on important issues related to MDSC biology, including expansion and activation of MDSC, phenotype, and subsets as well pathways and different mechanisms by which these cells exert their suppressive effect. Recent observations suggesting that MDSC may have roles in transplant tolerance are presented. Although therapeutic targeting and destruction of MDCS is of primary interest in cancer patients, in transplantation it will instead be necessary to induce, expand, and activate these cells; thus current possibilities for in vitro generation of MDSC are also discussed.

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