Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 1991 May;47(5):325-9.

Use of pyruvic acid in the treatment of actinic keratoses: a clinical and histopathologic study

Affiliations
  • PMID: 2070654
Clinical Trial

Use of pyruvic acid in the treatment of actinic keratoses: a clinical and histopathologic study

T D Griffin et al. Cutis. 1991 May.

Abstract

Twelve patients with multiple actinic keratoses were treated with either 5-fluorouracil and pyruvic acid or pyruvic acid alone. Three patients were treated with 5 percent 5-fluorouracil cream for one to three weeks for comparison. Exposure time to alpha-hydroxy acids varied between one and ten minutes. Biopsy specimens were taken at times varying from immediately after treatment to eight weeks after treatment. The results show that the combination of 5-fluorouracil and pyruvic acid is an effective treatment for actinic keratoses. In addition, the exposure time to 5-fluorouracil is decreased and therefore this treatment is better tolerated than prolonged treatment with 5-fluorouracil alone.

PubMed Disclaimer

Similar articles

Cited by

  • [Chemical peels].
    Schürer NY, Wiest L. Schürer NY, et al. Hautarzt. 2006 Jan;57(1):61-76; quiz 77. doi: 10.1007/s00105-005-1081-8. Hautarzt. 2006. PMID: 16397809 Review. German.
  • Interventions for actinic keratoses.
    Gupta AK, Paquet M, Villanueva E, Brintnell W. Gupta AK, et al. Cochrane Database Syst Rev. 2012 Dec 12;12(12):CD004415. doi: 10.1002/14651858.CD004415.pub2. Cochrane Database Syst Rev. 2012. PMID: 23235610 Free PMC article.