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. 2010:2010:586090.
doi: 10.1155/2010/586090. Epub 2010 Jul 27.

High-Speed Burring with and without the Use of Surgical Adjuvants in the Intralesional Management of Giant Cell Tumor of Bone: A Systematic Review and Meta-Analysis

H Algawahmed  1 , Robert Turcotte, F Farrokhyar, M Ghert
Affiliations

High-Speed Burring with and without the Use of Surgical Adjuvants in the Intralesional Management of Giant Cell Tumor of Bone: A Systematic Review and Meta-Analysis

H Algawahmed et al. Sarcoma. 2010.

Abstract

Local control rates for Giant Cell Tumor of Bone (GCT) have been reported in a large number of retrospective series. However, there remains a lack of consensus with respect to the need for a surgical adjuvant when intralesional curettage is performed. We have systematically reviewed the literature and identified six studies in which two groups from the same patient cohort were treated with intralesional curettage and high-speed burring with or without a chemical or thermal adjuvant. Studies were evaluated for quality and pooled data was analyzed using the fixed effects model. Data from 387 patients did not indicate improved local control with the use of surgical adjuvants. Given the available data, we conclude that surgical adjuvants are not required when meticulous tumor removal is performed.

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Figures

Figure 1
Figure 1
Literature search flow diagram.
Figure 2
Figure 2
Forest plot for odds ratios of overall recurrence by type of intervention (95% CI, 0.67–3.35,  P = .32).
Figure 3
Figure 3
The funnel plot for the 6 studies included in the meta-analysis. The plot shows asymmetrical distribution indicating some publication bias in favor of studies showing an effect for the use of an adjuvant (to the left).
See this image and copyright information in PMC

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