Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Oct;128(4):461-3.
doi: 10.1007/s00439-010-0871-y. Epub 2010 Aug 13.

Identification of an autosomal recessive stuttering locus on chromosome 3q13.2-3q13.33

Muhammad Hashim Raza  1 , Sheikh Riazuddin, Dennis Drayna
Affiliations

Identification of an autosomal recessive stuttering locus on chromosome 3q13.2-3q13.33

Muhammad Hashim Raza et al. Hum Genet. 2010 Oct.

Abstract

Stuttering is a common speech disorder with substantial genetic contributions. To better understand the genetic factors involved in stuttering, we performed a genome-wide linkage study in a newly-ascertained consanguineous stuttering family from Pakistan. A linkage scan in this family using parametric linkage analysis revealed significant linkage only on chromosome 3q13.2-3q13.33, with a maximum two-point LOD score of 4.23 under an autosomal recessive model of inheritance.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Pedigree of Pakistani stuttering family PKST77. Filled symbols represent affected individuals. Double horizontal lines represent the consanguineous marriage. The disease associated haplotype is shown in vertical boxes
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Hoffmann K, Lindner TH. easyLINKAGE-Plus—automated linkage analyses using large-scale SNP data. Bioinformatics. 2005;21(17):3565–3567. - PubMed
    1. Kang C, Riazuddin S, Mundorff J, Krasnewich D, Friedman P, Mulikan J, Drayna D. Mutations in the lysosomal enzyme-targeting pathway and persistent stuttering. N Engl J Med. 2010;362:677–685. - PMC - PubMed
    1. Lan J, Song M, Pan C, Zhuang G, Wang Y, Ma W, Chu Q, Lai Q, Xu F, Li Y, Liu L, Wang W. Association between dopaminergic genes (SLC6A3 and DRD2) and stuttering among Han Chinese. J Hum Genet. 2009;54(8):457–460. - PubMed
    1. Riaz N, Steinberg S, Ahmad J, Pluzhnikov A, Riazuddin S, Cox NJ, Drayna D. Genomewide significant linkage to stuttering on chromosome 12. Am J Hum Genet. 2005;76(4):647–651. - PMC - PubMed
    1. Shugart YY, Mundorff J, Kilshaw J, Doheny K, Doan B, Wanyee J, Green ED, Drayna D. Results of a genome-wide linkage scan for stuttering. Am J Med Genet A. 2004;124A(2):133–135. - PubMed