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Review
. 2010 Sep 15;51(6):725-31.
doi: 10.1086/655889.

Rethinking prevention of HIV type 1 infection

David N Burns  1 , Carl W Dieffenbach, Sten H Vermund
Affiliations
Review

Rethinking prevention of HIV type 1 infection

David N Burns et al. Clin Infect Dis. .

Erratum in

  • Clin Infect Dis. 2010 Oct 15;51(8):995

Abstract

Research on the prevention of human immunodeficiency virus (HIV)-1 infection is at a critical juncture. Major methodological challenges to performing prevention trials have emerged, and one after another promising biomedical interventions have failed to reduce the incidence of HIV-1 infection. Nevertheless, there is growing optimism that progress can be achieved in the near term. Mathematical modeling indicates that 2 new strategies, "test and treat" and preexposure prophylaxis, could have a major impact on the incidence of HIV-1 infection. Will our hopes be justified? We review the potential strengths and limitations of these antiretroviral "treatment as prevention" strategies and outline other new options for reducing the incidence of HIV-1 infection in the near term. By maximizing the potential of existing interventions, developing other effective strategies, and combining them in an optimal manner, we have the opportunity to bring the HIV-1 epidemic under control.

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Figures

Figure. 1
Figure. 1
The test, link, and treat cascade. Gaps limiting the impact of human immunodeficiency virus (HIV)–1 testing and treatment on achievement of viral suppression. Data from [29, 30, 33, 34].
See this image and copyright information in PMC

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