doi: 10.1016/j.ejmech.2010.07.021.
Epub 2010 Aug 12.
Synthesis and biological property of some novel 1,3,4-oxadiazoles
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- PMID: 20708305
- DOI: 10.1016/j.ejmech.2010.07.021
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Synthesis and biological property of some novel 1,3,4-oxadiazoles
Eur J Med Chem.
2010 Oct.
Abstract
A series of biphenyl-1,3,4-oxadiazoles namely 5-[substituted-(1,1'-biphenyl)-3-yl]-1,3,4-oxadiazole-2(3H)-thiones and its S-alkyl derivatives have been synthesized by multi step organic synthesis involving Suzuki-Miyaura coupling using palladium catalyst. The synthesized compounds were characterized by (1)H NMR, (13)C NMR, (19)F NMR, IR and LCMS spectroscopic properties. They were tested for their antimicrobial and analgesic activities. Some of them showed significant activity.
Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.
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