Getting one's Fak straight
- PMID: 20708578
- PMCID: PMC2967025
- DOI: 10.1016/j.devcel.2010.07.023
Getting one's Fak straight
Abstract
Focal adhesion kinase (FAK) is a pivotal regulator of integrin signaling and responses to cell adhesive dynamics. In this issue of Developmental Cell, Ashton et al. demonstrate that Fak is critical for intestinal oncogenesis and regeneration after injury but not for day-to-day homeostasis, providing novel insights into intestinal biology and colorectal cancer therapy.
2010 Elsevier Inc. All rights reserved.
Comment on
-
Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling.Dev Cell. 2010 Aug 17;19(2):259-69. doi: 10.1016/j.devcel.2010.07.015. Dev Cell. 2010. PMID: 20708588 Free PMC article.
References
-
- Ashton, et al. this issue.
-
- Batlle E, Henderson JT, Beghtel H, van den Born MM, Sancho E, Huls G, Meeldijk J, Robertson J, van de Wetering M, Pawson T, et al. Cell. 2002;111:251–263. - PubMed
-
- He TC, Sparks AB, Rago C, Hermeking H, Zawel L, da Costa LT, Morin PJ, Vogelstein B, Kinzler KW. Science. 1998;281:1509–1512. - PubMed
Publication types
Grants and funding
LinkOut - more resources
Full Text Sources
Miscellaneous