On the fast track to organizer gene expression

doi:10.1016/j.devcel.2010.07.020

Comment

. 2010 Aug 17;19(2):190-2.

doi: 10.1016/j.devcel.2010.07.020.

On the fast track to organizer gene expression

David Kimelman¹

Affiliations

PMID: 20708581
PMCID: PMC5568668
DOI: 10.1016/j.devcel.2010.07.020

Comment

On the fast track to organizer gene expression

David Kimelman. Dev Cell. 2010.

. 2010 Aug 17;19(2):190-2.

doi: 10.1016/j.devcel.2010.07.020.

Author

David Kimelman¹

Affiliation

¹ Department of Biochemistry, University of Washington, Seattle, 98195-7350, USA. kimelman@u.washington.edu

PMID: 20708581
PMCID: PMC5568668
DOI: 10.1016/j.devcel.2010.07.020

Abstract

Many embryonic species are initially transcriptionally quiescent after fertilization. In this issue of Developmental Cell, Blythe et al. reveal that beta-catenin acts very early in Xenopus development to specifically modify the chromatin of organizer genes, poising them for rapid activation when transcription begins.

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Figures

**Figure 1**
Regulation of Organizer gene expression in the early Xenopus embryo

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Comment on

beta-Catenin primes organizer gene expression by recruiting a histone H3 arginine 8 methyltransferase, Prmt2.
Blythe SA, Cha SW, Tadjuidje E, Heasman J, Klein PS. Blythe SA, et al. Dev Cell. 2010 Aug 17;19(2):220-31. doi: 10.1016/j.devcel.2010.07.007. Dev Cell. 2010. PMID: 20708585 Free PMC article.

Cited by

An essential role for transcription before the MBT in Xenopus laevis.
Skirkanich J, Luxardi G, Yang J, Kodjabachian L, Klein PS. Skirkanich J, et al. Dev Biol. 2011 Sep 15;357(2):478-91. doi: 10.1016/j.ydbio.2011.06.010. Epub 2011 Jun 29. Dev Biol. 2011. PMID: 21741375 Free PMC article.

References

1. Belenkaya TY, Han C, Standley HJ, Lin X, Houston DW, Heasman J. pygopus Encodes a nuclear protein essential for wingless/Wnt signaling. Development. 2002;129:4089–4101. - PubMed
1. De Robertis EM. Spemann’s organizer and the self-regulation of embryonic fields. Mech Dev. 2009;126:925–941. - PMC - PubMed
1. Kennedy MW, Cha SW, Tadjuidje E, Andrews PG, Heasman J, Kao KR. A co-dependent requirement of xBcl9 and Pygopus for embryonic body axis development in Xenopus. Dev Dyn. 2010;239:271–283. - PubMed
1. Larabell CA, Torres M, Rowning BA, Yost C, Miller JR, Wu M, Kimelman D, Moon RT. Establishment of the dorso-ventral axis in Xenopus embryos is presaged by early asymmetries in β-catenin that are modulated by the Wnt signaling pathway. J Cell Biol. 1997;136:1123–1136. - PMC - PubMed
1. Mosimann C, Hausmann G, Basler K. B-catenin hits chromatin: regulation of Wnt target gene activation. Nat Rev Mol Cell Biol. 2009;10:276–286. - PubMed

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[1] Belenkaya TY, Han C, Standley HJ, Lin X, Houston DW, Heasman J. pygopus Encodes a nuclear protein essential for wingless/Wnt signaling. Development. 2002;129:4089–4101. - PubMed

[2] Belenkaya TY, Han C, Standley HJ, Lin X, Houston DW, Heasman J. pygopus Encodes a nuclear protein essential for wingless/Wnt signaling. Development. 2002;129:4089–4101. - PubMed

[3] De Robertis EM. Spemann’s organizer and the self-regulation of embryonic fields. Mech Dev. 2009;126:925–941. - PMC - PubMed

[4] De Robertis EM. Spemann’s organizer and the self-regulation of embryonic fields. Mech Dev. 2009;126:925–941. - PMC - PubMed

[5] Kennedy MW, Cha SW, Tadjuidje E, Andrews PG, Heasman J, Kao KR. A co-dependent requirement of xBcl9 and Pygopus for embryonic body axis development in Xenopus. Dev Dyn. 2010;239:271–283. - PubMed

[6] Kennedy MW, Cha SW, Tadjuidje E, Andrews PG, Heasman J, Kao KR. A co-dependent requirement of xBcl9 and Pygopus for embryonic body axis development in Xenopus. Dev Dyn. 2010;239:271–283. - PubMed

[7] Larabell CA, Torres M, Rowning BA, Yost C, Miller JR, Wu M, Kimelman D, Moon RT. Establishment of the dorso-ventral axis in Xenopus embryos is presaged by early asymmetries in β-catenin that are modulated by the Wnt signaling pathway. J Cell Biol. 1997;136:1123–1136. - PMC - PubMed

[8] Larabell CA, Torres M, Rowning BA, Yost C, Miller JR, Wu M, Kimelman D, Moon RT. Establishment of the dorso-ventral axis in Xenopus embryos is presaged by early asymmetries in β-catenin that are modulated by the Wnt signaling pathway. J Cell Biol. 1997;136:1123–1136. - PMC - PubMed

[9] Mosimann C, Hausmann G, Basler K. B-catenin hits chromatin: regulation of Wnt target gene activation. Nat Rev Mol Cell Biol. 2009;10:276–286. - PubMed

[10] Mosimann C, Hausmann G, Basler K. B-catenin hits chromatin: regulation of Wnt target gene activation. Nat Rev Mol Cell Biol. 2009;10:276–286. - PubMed

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On the fast track to organizer gene expression

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On the fast track to organizer gene expression

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