On the fast track to organizer gene expression
- PMID: 20708581
- PMCID: PMC5568668
- DOI: 10.1016/j.devcel.2010.07.020
On the fast track to organizer gene expression
Abstract
Many embryonic species are initially transcriptionally quiescent after fertilization. In this issue of Developmental Cell, Blythe et al. reveal that beta-catenin acts very early in Xenopus development to specifically modify the chromatin of organizer genes, poising them for rapid activation when transcription begins.
2010 Elsevier Inc. All rights reserved.
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Comment on
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beta-Catenin primes organizer gene expression by recruiting a histone H3 arginine 8 methyltransferase, Prmt2.Dev Cell. 2010 Aug 17;19(2):220-31. doi: 10.1016/j.devcel.2010.07.007. Dev Cell. 2010. PMID: 20708585 Free PMC article.
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