Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2010;15(9):961-4.
doi: 10.1634/theoncologist.2010-0070. Epub 2010 Aug 13.

Lenalidomide-induced acute interstitial nephritis

Evan J Lipson  1 , Carol Ann Huff, Danniele G Holanda, Michael A McDevitt, Derek M Fine
Affiliations
Case Reports

Lenalidomide-induced acute interstitial nephritis

Evan J Lipson et al. Oncologist. 2010.

Abstract

The first case of biopsy-proven lenalidomide-induced acute interstitial nephritis is presented.

PubMed Disclaimer

Conflict of interest statement

Disclosures: Evan J. Lipson: None; Carol Ann Huff: Consultant/advisory role: Celgene, Amgen; Research funding/contracted research: Geron, Bristol-Myers Squibb; Danniele G. Holanda: None; Michael A. McDevitt: None; Derek M. Fine: None.

The content of this article has been reviewed by independent peer reviewers to ensure that it is balanced, objective, and free from commercial bias. No financial relationships relevant to the content of this article have been disclosed by the independent peer reviewers.

Figures

Figure 1.
Figure 1.
Lab values and medication doses.
Figure 2.
Figure 2.
Renal biopsy consistent with acute and early chronic drug-induced interstitial nephritis. (A): A mixed interstitial infiltrate of lymphoplasmacytic cells, predominantly eosinophils. Moderate tubular injury was also noted, with tubular cell swelling, vacuolization, focal simplification of tubules with bland casts, and reactive and regenerative changes. (Masson Trichrome; 160×) (B): Interstitial nephritis with eosinophils in the medullary parenchyma. (H&E; 64×)
See this image and copyright information in PMC

References

    1. Batts ED, Sanchorawala V, Hegerfeldt Y, et al. Azotemia associated with use of lenalidomide in plasma cell dyscrasias. Leuk Lymphoma. 2008;49:1108–1115. - PubMed
    1. Markowitz GS, Fine PL, Stack JI, et al. Toxic acute tubular necrosis following treatment with zoledronate (Zometa) Kidney Int. 2003;64:281–289. - PubMed
    1. Chang JT, Green L, Beitz J. Renal failure with the use of zoledronic acid. N Engl J Med. 2003;349:1676–1679. discussion 1676–1679. - PubMed
    1. Guarneri V, Donati S, Nicolini M, et al. Renal safety and efficacy of i.v. bisphosphonates in patients with skeletal metastases treated for up to 10 years. The Oncologist. 2005;10:842–848. - PubMed
    1. Fernández-Fresnedo G, de Francisco AL, Rodrigo E, et al. [“Occult” renal insufficiency due to evaluating renal function using only serum creatinine.] Nefrologia. 2002;22:144–151. In Spanish. - PubMed

Publication types