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Case Reports
. 2010 Aug;22(3):330-2.
doi: 10.5021/ad.2010.22.3.330. Epub 2010 Aug 5.

A case of clear cell eccrine porocarcinoma

Yeon Ju Hong  1 , Ji Eun Oh, You Won Choi, Ki Bum Myung, Hae Young Choi
Affiliations
Case Reports

A case of clear cell eccrine porocarcinoma

Yeon Ju Hong et al. Ann Dermatol. 2010 Aug.

Abstract

Eccrine porocarcinoma (EP) is a rare malignant tumor arising from the intraepidermal eccrine duct. The tumor cells frequently contain glycogen, but prominent clear cell changes in EP are rarely reported. A 78-year-old woman presented with a slightly pruritic, erythematous, verrucous plaque on her left thigh. Histopathological examination revealed intraepidermal tumor cell nests composed of small basaloid cells and duct-like structures lined by periodic acid-Schiff (PAS)-positive cuticles. Besides the typical findings of EP, clear cell changes were predominantly observed in the tumor cell aggregations. Herein we report a case of the clear cell variant of EP rarely reported in previous literature.

Keywords: Clear cell; Eccrine porocarcinoma; Malignant eccrine poroma.

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Figures

Fig. 1
Fig. 1
A 2×2 cm sized, erythematous plaque with focal erosions on the left thigh.
Fig. 2
Fig. 2
(A) The intraepidermal aggregations were composed of small basaloid cells with sharp demarcations. Prominent clear cell changes were also noted within the tumor nests (H&E, ×40). (B) Acrosyringium-like, spiral ductal structures were seen in some aggregations (H&E, ×100).
Fig. 3
Fig. 3
(A) In addition to atypical tumor cells, numerous clear cells with ample cytoplasm were observed (H&E, ×400). (B) PAS-positive diastase-labile granules were seen in the cytoplasm of clear cells (×400).
Fig. 4
Fig. 4
(A) Immunoreactivity for EMA showed focal positivity within the tumor cells (×40). (B) Immunoreactivity for CEA was restricted to the border of the ductal structures (×100).
See this image and copyright information in PMC

References

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