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. 1991 Jun;10(2):327-32.
doi: 10.1016/0888-7543(91)90315-6.

Aland eye disease: linkage data

M Schwartz  1 , T Rosenberg
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Aland eye disease: linkage data

M Schwartz et al. Genomics. 1991 Jun.

Abstract

A large Danish family with Aland Island eye disease (AIED) was studied by linkage analysis using 16 polymorphic DNA markers covering the whole X chromosome. Positive lod scores were found for marker loci at the proximal part of the short arm of the X chromosome, DXS255 and TIMP (Zmax = 3.93 and 3.18 at theta = 0.0), suggesting an assignment of the locus for AIED to this part of the X chromosome. Recombination was observed with the locus DXS7 as well as with other loci distal to DXS7. These results are not in agreement with the deletion presented previously by D-A. M. Pillers et al. (1990, Am. J. Med. Genet. 36: 23-28), which mapped AIED to Xp21.

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