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. 2011 Mar;41(3):332-40.
doi: 10.1007/s10803-010-1055-2.

Early developmental regression in autism spectrum disorder: evidence from an international multiplex sample

Jeremy R Parr  1 , Ann Le Couteur, Gillian Baird, Michael Rutter, Andrew Pickles, Eric Fombonne, Anthony J Bailey; International Molecular Genetic Study of Autism Consortium (IMGSAC) Members
Collaborators, Affiliations

Early developmental regression in autism spectrum disorder: evidence from an international multiplex sample

Jeremy R Parr et al. J Autism Dev Disord. 2011 Mar.

Abstract

The characteristics of early developmental regression (EDR) were investigated in individuals with ASD from affected relative pairs recruited to the International Molecular Genetic Study of Autism Consortium (IMGSAC). Four hundred and fifty-eight individuals with ASD were recruited from 226 IMGSAC families. Regression before age 36 months occurred in 23.9% of individuals. The observed concordance rate for EDR within sibling pairs (18.9%) was not significantly above the rate expected under independence (13.5%, p = 0.10). The rate of regression in individuals with ASD from multiplex families was similar to that reported in singleton and epidemiological samples. Regression concordance data were not supportive of a separate familial influence on EDR, other than as a part of autism itself.

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References

    1. J Am Acad Child Psychiatry. 1985 Mar;24(2):191-6 - PubMed
    1. Arch Gen Psychiatry. 2007 Jul;64(7):853-64 - PubMed
    1. J Autism Dev Disord. 1992 Jun;22(2):175-88 - PubMed
    1. J Autism Dev Disord. 2005 Jun;35(3):337-50 - PubMed
    1. Pediatrics. 2001 Oct;108(4):E58 - PubMed

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