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. 2010 Oct;117(10):1155-60.
doi: 10.1007/s00702-010-0460-1. Epub 2010 Aug 15.

Social play impairment following status epilepticus during early development

Adelisandra Silva Santos Castelhano  1 , Fulvio Alexandre Scorza, Maria Cristina Triguero Veloz Teixeira, Ricardo Mario Arida, Esper Abrão Cavalheiro, Roberta Monterazzo Cysneiros
Affiliations

Social play impairment following status epilepticus during early development

Adelisandra Silva Santos Castelhano et al. J Neural Transm (Vienna). 2010 Oct.

Abstract

Neonatal status epilepticus (SE) disrupts prefrontal cortex and thalamus, brain regions related to social play. Juvenile play was evaluated using the "intruder-resident" paradigm following SE in 9-day-old Wistar pups of both genders. Quite interestingly, we demonstrated for the first time that neonatal SE produces social impairment in male rats, reduces locomotor activity in both genders and enhances self-grooming in female. Additional studies are necessary to clarify if these effects can impair social behavior across the life span.

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