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. 1991 Mar;29(3):92-5.

Pharmacokinetics of nicotine after application of a 30 cm2 nicotine patch under steady-state conditions

S Caspary  1 , B Keller-Stanislawski, T Huber, P G Merz
Affiliations
  • PMID: 2071260

Pharmacokinetics of nicotine after application of a 30 cm2 nicotine patch under steady-state conditions

S Caspary et al. Int J Clin Pharmacol Ther Toxicol. 1991 Mar.

Abstract

Transdermal nicotine systems (Nicotinell 30) were applied daily to the skin of healthy nicotine-dependent smokers for 4 days. Blood samples were taken for the measurement of nicotine and cotinine in plasma using capillary gas chromatography with nitrogen detection. The plasma concentration-time profiles of nicotine and cotinine and the pharmacokinetic parameters cmax, tmax, AUC and the elimination half-life were determined under steady-state conditions. Nicotine levels after application of the 30 cm2 patch were in accord with published values for 10, 20 and 2 x 20 cm2 patches. The elimination half-life of nicotine after removal of the patch was longer than reported values obtained after i.v. application.

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