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Review
. 2010 Oct;54(1):195-206.
doi: 10.1111/j.1600-0757.2010.00373.x.

Epithelial cell-derived antimicrobial peptides are multifunctional agents that bridge innate and adaptive immunity

Thomas S McCormick, Aaron Weinberg
Review

Epithelial cell-derived antimicrobial peptides are multifunctional agents that bridge innate and adaptive immunity

Thomas S McCormick et al. Periodontol 2000. 2010 Oct.
No abstract available

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Figures

Figure 1
Figure 1. Immunofluorescence detection of human β-defensin (hBD) 2 and 3 in normal oral epithelium
Formalin fixed and parafin embedded normal human oral tissue was labeled with an anti-human β-defensin 2 specific primary antibody, and detected with AlexaFluor 488 (green) conjugated secondary antibody. Human β-defensin 3 was labeled with specific primary antibodies and detected using an AlexaFluor 594 (purple) conjugated donkey anti-rabbit. Note green fluorescence detection of β-defensin 2 localized to the stratum spinosum and straum granulosum, while pink/red fluorescence detects human β-defensin 3 exclusively to the stratum basale. β-defensin 1, not shown, is localized to the same regions as β-defensin 2 (20). (Courtesy of Dr. Ge Jin, Dept. Biological Sciences, Case Western Reserve Univ, School of Dental Medicine)
Figure 2
Figure 2. AMP's direct chemotaxis indirectly
Certain bacterial challenge (as depicted by Fusobacterium nucleatum) results in defensin upregulation and release from oral epithelial cells. Defensins in turn induce chemokine production (monocyte chemotactic protein-1 (MCP-1), macrophage inflammatory protein-3α (MIP-3α), interferon-γ inducible protein-10 (IP-10)) that elicit recruitment of monocyte precursors such as immature dendritic cells. Upon contact with defensins via Toll-like receptors, immature cells mature and express co-stimulatory molecules (see below). Lc, Langerhans cell.
Figure 3
Figure 3. Expression of human β-defensin (hBD) 2 and human β-defensin 3 in carcinoma in situ
carcinoma in situ (CIS) biopsy sections were stained with hematoxilin & eosin stain (upper panel) and double immunofluorescence using antibodies to human β-defensin-2 (green) and human β-defensin-3 (red) (lower panel), respectively. The carcinoma in situ lesion and adjacent normal epithelium are separated by the dashed white line in the enlarged inset (lowest panel). (courtesy of Kawsar et al, 2009)
See this image and copyright information in PMC

References

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