TLR-based immune adjuvants
- PMID: 20713100
- PMCID: PMC3000864
- DOI: 10.1016/j.vaccine.2010.08.002
TLR-based immune adjuvants
Abstract
This work describes the nature and strength of the immune response induced by various Toll-like receptor ligands and their ability to act as vaccine adjuvants. It reviews the various ligands capable of triggering individual TLRs, and then focuses on the efficacy and safety of those agents for which clinical results are available.
Published by Elsevier Ltd.
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References
-
- Janeway CA, Jr., Medzhitov R. Innate immune recognition. Annu Rev Immunol. 2002;20:197–216.. 197–216. - PubMed
-
- Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell. 2006 Feb 24;124(4):783–801. - PubMed
-
- Medzhitov R. Recognition of microorganisms and activation of the immune response. Nature. 2007 Oct 18;449(7164):819–26. - PubMed
-
- Pasare C, Medzhitov R. Toll-like receptors and acquired immunity. Semin Immunol. 2004 Feb;16(1):23–6. - PubMed
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