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Comment
. 2010 Aug 15;24(16):1673-9.
doi: 10.1101/gad.1964810.

Merlin in organ size control and tumorigenesis: Hippo versus EGFR?

Chunling Yi  1 , Joseph L Kissil
Affiliations
Comment

Merlin in organ size control and tumorigenesis: Hippo versus EGFR?

Chunling Yi et al. Genes Dev. .

Abstract

The role of the NF2 gene as a tumor suppressor has been well established. In this issue of Genes & Development, Benhamouche and colleagues (pp. 1718-1730) demonstrate that NF2 is also involved in the regulation of organ size control in mammals. Conditional knockout of Nf2 in the mouse liver results in massive organ enlargement and eventual tumor development, which is attributed to the specific expansion of oval cells. Here we discuss these findings and the proposed molecular mechanisms involved within the context of our current understanding of the pathways regulated by NF2.

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Figures

Figure 1.
Figure 1.
Schematic representation of currently identified points of interaction between Merlin and the Hpo/Yap and Ras/Rac signaling pathways discussed here. Merlin has been shown to function as a regulator of additional signaling mechanisms; however, these interactions were omitted for clarity.
See this image and copyright information in PMC

Comment on

References

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