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. 2010 Sep;30(9):1041-8.
doi: 10.1177/0333102409359091. Epub 2010 Apr 27.

On the methodology of drug trials in migraine with aura

Anne Werner Hauge  1 , Anders Hougaard, Jes Olesen
Affiliations

On the methodology of drug trials in migraine with aura

Anne Werner Hauge et al. Cephalalgia. 2010 Sep.

Abstract

Introduction: Specific problems occur in clinical treatment trials for migraine with aura that differ from those encountered in treatment trials for migraine without aura.

Discussion: Based on our experience with four such trials, we point to a number of possible solutions and outline areas for future inquiry. We make recommendations about subject selection; the choice, definition and assessment of outcome measures; optimal treatments in relation to aura and headache; and we provide samples of study report forms used to record occurrence of aura and headache in this population.

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