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. 1991 Apr;12(2):181-5.
doi: 10.1007/BF02337031.

Increased acetylcholine sensitivity in Duchenne muscular dystrophy myotubes

G Meola  1 , E Mancinelli, L Geremia, G Scarlato
Affiliations

Increased acetylcholine sensitivity in Duchenne muscular dystrophy myotubes

G Meola et al. Ital J Neurol Sci. 1991 Apr.

Abstract

Monolayer cultures were established from explants of muscle obtained from 6 patients with Duchenne muscular dystrophy (DMD) and 9 controls. Electrophysiological studies were made after 3-4 weeks in vitro, when many myotubes had formed. An intracellular electrode was used to record cell membrane potential, and acetylcholine was applied by ionophoresis. The myotubes grown from Duchenne muscle showed greater acetylcholine sensitivity than controls.

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