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. 2010 Jul 29;15(8):5124-38.
doi: 10.3390/molecules15085124.

Antiplatelet aggregation and platelet activating factor (PAF) receptor antagonistic activities of the essential oils of five Goniothalamus species

Bushra Abdulkarim Moharam  1 , Ibrahim Jantan, Fasihuddin bin Ahmad, Juriyati Jalil
Affiliations

Antiplatelet aggregation and platelet activating factor (PAF) receptor antagonistic activities of the essential oils of five Goniothalamus species

Bushra Abdulkarim Moharam et al. Molecules. .

Abstract

Nine essential oils, hydrodistilled from different parts of five Goniothalamus species (G. velutinus Airy-Shaw, G. woodii Merr., G. clemensii Ban, G. tapis Miq. and G. tapisoides Mat Salleh) were evaluated for their ability to inhibit platelet aggregation in human whole blood using an electrical impedance method and their inhibitory effects on platelet activating factor (PAF) receptor binding with rabbit platelets using 3H-PAF as a ligand. The chemical composition of the oils was analyzed by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). The bark oil of G. velutinus was the most effective sample as it inhibited both arachidonic acid (AA) and ADP-induced platelet aggregation with IC(50) values of 93.6 and 87.7 microg/mL, respectively. Among the studied oils, the bark oils of G. clemensii, G. woodii, G. velutinus and the root oil of G. tapis showed significant inhibitory effects on PAF receptor binding, with IC(50 )values ranging from 3.5 to 10.5 microg/mL. The strong PAF antagonistic activity of the active oils is related to their high contents of sesquiterpenes and sesquiterpenoids, and the individual components in the oils could possibly produce a synergistic effect in the overall antiplatelet activity of the oils.

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Figures

Figure 1
Figure 1
Inhibitory effects the leaf (L), bark (B) and root (R) oils of Goniothalamus and standards (18.2 µg/mL) on 3H-PAF binding to PAF receptor on rabbit platelets. Cedrol was used as a positive control. Each point represents the mean of three experiments, each in triplicate. Standard deviation of the mean are indicated as vertical bars. *p < 0.05 as compared with the respective control.
Figure 2
Figure 2
Inhibitory effect of the leaf (L), bark (B) and root (R) oils of Goniothalamus tapis, bark oils of G. woodii, G. clemensii and G. velutinus and cedrol on PAF receptor binding to rabbit platelets. Each point represents the mean of three experiments, each in triplicate. Standard deviation of the mean are indicated as vertical bars.
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References

    1. Saunders R.M.K. A synopsis of Goniothalamus species (Annonaceae) in Peninsular Malaysia, with a description of a new species. Bot. J. Linnean Soc. 2003;142:321–339. doi: 10.1046/j.1095-8339.2003.00177.x. - DOI
    1. Burkill I.H. A Dictionary of the Economic Products of the Malay Peninsular. Ministry of Agriculture and Co-operative; Kuala Lumpur, Malaysia: 1966.
    1. Seidel V., Bailleul F., Waterman P.G. (Rel)-1β,2α-di-(2,4-dihydroxy-6-methoxybenzoyl)-3β,4α-di-(4-methoxyphenyl )-cyclobutane and other flavonoids from the aerial parts of Goniothalamus gardneri and Goniothalamus thwaitesii. Phytochemistry. 2000;55:439–446. doi: 10.1016/S0031-9422(00)00346-0. - DOI - PubMed
    1. Zhang Y.J., Kong M., Chen R.Y., Yu D.Q. Alkaloids from the roots of Goniothalamus griffithii. J. Nat. Prod. 1999;62:1050–1052. doi: 10.1021/np990004l. - DOI - PubMed
    1. Alali F.Q., Liu X.X., McLaughlin J.L. Annonaceous acetogenins: Recent progress. J. Nat. Prod. 1999;62:504–540. doi: 10.1021/np980406d. - DOI - PubMed

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