doi: 10.1016/0883-2897(91)90131-4.
A new method for labelling of monoclonal antibodies and their fragments with technetium-99m
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- PMID: 2071447
- DOI: 10.1016/0883-2897(91)90131-4
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A new method for labelling of monoclonal antibodies and their fragments with technetium-99m
Int J Rad Appl Instrum B.
1991.
Abstract
A new method of labelling of antibodies with technetium-99m is described. The antibody or fragment is derivatized by iminothiolane. Ligand exchange from a labile technetium complex such as TcO(GLU)2- results in greater than 90% of the technetium labelling the antibody. This method appears to be equally applicable to antibodies and fragments.
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