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. 1991;18(3):353-6.
doi: 10.1016/0883-2897(91)90131-4.

A new method for labelling of monoclonal antibodies and their fragments with technetium-99m

E Joiris  1 , B Bastin, J R Thornback
Affiliations

A new method for labelling of monoclonal antibodies and their fragments with technetium-99m

E Joiris et al. Int J Rad Appl Instrum B. 1991.

Abstract

A new method of labelling of antibodies with technetium-99m is described. The antibody or fragment is derivatized by iminothiolane. Ligand exchange from a labile technetium complex such as TcO(GLU)2- results in greater than 90% of the technetium labelling the antibody. This method appears to be equally applicable to antibodies and fragments.

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