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Review
. 2010 Sep;160(17-18):458-63.
doi: 10.1007/s10354-010-0812-3. Epub 2010 Aug 16.

An antibody against RANKL for the treatment of osteoporosis, inflammatory and malignant bone diseases

Eduardo Maldonado-Gonzales  1 , Peter Pietschmann
Affiliations
Review

An antibody against RANKL for the treatment of osteoporosis, inflammatory and malignant bone diseases

Eduardo Maldonado-Gonzales et al. Wien Med Wochenschr. 2010 Sep.

Abstract

Over the years, the importance of receptor activator of nuclear factor κB ligand (RANKL) in bone physiology and pathophysiology has been thoroughly documented. Denosumab, also known as AMG 162, is a fully human monoclonal antibody against RANKL which is being studied in the treatment of metabolic, inflammatory, and malignant bone diseases. The purpose of this review is to analyze the potential role of denosumab in osteoporosis, rheumatoid arthritis, bone metastases and multiple myeloma.

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