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Review
. 2011 Jan;12(1):85-98.
doi: 10.1517/14656566.2010.513701. Epub 2010 Aug 17.

Management of depression in patients with coronary heart disease: association, mechanisms, and treatment implications for depressed cardiac patients

Jenny T Wang  1 , Benson Hoffman, James A Blumenthal
Affiliations
Review

Management of depression in patients with coronary heart disease: association, mechanisms, and treatment implications for depressed cardiac patients

Jenny T Wang et al. Expert Opin Pharmacother. 2011 Jan.

Abstract

Importance of the field: Coronary heart disease (CHD) and depression are two leading causes of death and disability in the United States and worldwide. Depression is especially common in cardiac patients, and there is growing evidence that depression is a risk factor for fatal and nonfatal events in CHD patients.

Areas covered in this review: This paper reviews current literature of depression as a risk factor for CHD along with pharmacologic and non-pharmacologic treatments for depression in cardiac patients.

What the reader will gain: Readers will gain knowledge about the importance of depression as a CHD risk factor and learn the results of efforts to treat depressed CHD patients.

Take home message: Although randomized clinical trials (RCTs) of medication and non-pharmacologic therapies have not demonstrated that treating depression improves survival, there is evidence that treating depressed patients can reduce depressive symptoms and improve quality of life. Additional RCTs are needed, including evaluation of non-pharmacologic therapies such as exercise, to examine the effects of treatment of depression on medical and psychosocial outcomes.

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Conflict of interest statement

Declaration of interest

The authors state no conflict of interest and have received no payment in preparation of this manuscript. The authors are supported by grants: HL080664 and HL093374 from the National Institutes of Health.

References

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