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Review
. 2010 Aug;3(4):401-8.
doi: 10.1161/CIRCEP.109.921056.

Short QT syndrome: from bench to bedside

Chinmay Patel  1 , Gan-Xin Yan, Charles Antzelevitch
Affiliations
Review

Short QT syndrome: from bench to bedside

Chinmay Patel et al. Circ Arrhythm Electrophysiol. 2010 Aug.
No abstract available

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Figures

Figure 1
Figure 1
A, Twelve-lead ECG showing characteristic ECG features of SQTS. B, Twelve-lead ECG showing characteristic ECG features of new clinical entity with combined ECG phenotype of Brugada syndrome in addition to SQTS. The ECG shows Brugada-type ST elevation in V1 and V2 after administration of ajmaline in addition to short QT interval. Modified from References and with permission. ,
Figure 2
Figure 2
A, Reduced rate-adaptation of QT interval. The QT-RR relationship is less linear and its slope is less steep in the SQTS patient as compared with control subjects. Quinidine restores the relationship toward control values. QTpV3 denotes the interval from the beginning of QRS complex to peak of T wave, measured in lead V3. Reproduced from Reference , with permission. B, Holter monitoring showing impaired adjustment of QT interval with change in heart rate.
Figure 3
Figure 3
PD-118057 (IKr agonist) model of SQTS in canine left ventricular wedge. A, PD-118057 induced abbreviation of QT interval and increase in TDR. Preferential abbreviation of epicardial action potential results in an increase in TDR. Each panel shows transmembrane action potentials simultaneously recorded from an epicardial (Epi) and a deep subendocardial M cell in an arterially perfused LV wedge preparation, together with a pseudo-ECG. Basic cycle length, 2000 ms. B, Programmed electric stimulation applied to epicardium induced polymorphic VT in the presence of PD-110857 but not after addition of quinidine. Basic cycle length, 2000 ms. Modified with permission.
Figure 4
Figure 4
Self-terminating episode of polymorphic VT in a patient with SQTS: Lead V3. The episode is precipitated by an extrasystole with a very short coupling interval.
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