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. 2010 Jan-Feb;3(1):71-3.
doi: 10.4161/oxim.3.1.10094.

Role of peroxiredoxin III in the pathogenesis of pre-eclampsia as evidenced in mice

Lianqin Li  1 , Masuo Obinata, Katsuyoshi Hori
Affiliations
Free PMC article

Role of peroxiredoxin III in the pathogenesis of pre-eclampsia as evidenced in mice

Lianqin Li et al. Oxid Med Cell Longev. 2010 Jan-Feb.
Free PMC article

Abstract

As a member of peroxiredoxin (Prx) family, PrxIII has been demonstrated to play an important role in scavenging intracellular reactive oxygen species (ROS). Since PrxIII knockout mice exhibited oxidative stress in placentas resembling pathophysiologic changes in placentas of human pre-eclampsia, we measured blood pressure through the carotid artery and detected oxidative status by Western blotting in pregnant mice. We did not notice hypertension in pregnant PrxIII knockout mice as compared with wild-type littermates, although endothelin-1 was over-expressed in PrxIII-deficient placentas. Our results indicate that PrxIII is not involved in pre-eclamptic development. Instead, PrxIII is an indispensable antioxidant in placentas where oxidative stress exists.

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Figures

Figure 1
Figure 1
Western blotting analysis for ET-1 expression in PrxIII+/+ (A) and PrxII −/− (B) mouse organs including (from 1 to 7) brain, heart, lung, liver, kidney, placenta and skeletal muscle. Signals for ET-1 protein were significantly enhanced in PrxII knockout placenta and kidney as compared with wild-type organs.
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