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. 2010 Nov;39(8):1215-9.
doi: 10.1097/MPA.0b013e3181e2d4a0.

Are genetic variants in the platelet-derived growth factor [beta] gene associated with chronic pancreatitis?

Venkata Muddana  1 , James Park, Janette Lamb, Dhiraj Yadav, Georgios I Papachristou, Robert H Hawes, Randall Brand, Adam Slivka, David C Whitcomb
Affiliations

Are genetic variants in the platelet-derived growth factor [beta] gene associated with chronic pancreatitis?

Venkata Muddana et al. Pancreas. 2010 Nov.

Abstract

Objectives: Platelet-derived growth factor [beta] (PDGF-[beta]) is a major signal in proliferation and matrix synthesis through activated pancreatic stellate cells, leading to fibrosis of the pancreas. Recurrent acute pancreatitis (RAP) seems to predispose to chronic pancreatitis (CP) in some patients but not others. We tested the hypothesis that 2 known PDGF-[beta] polymorphisms are associated with progression from RAP to CP. We also tested the hypothesis that PDGF-[beta] polymorphisms in combination with environmental risk factors such as alcohol and smoking are associated with CP.

Methods: Three hundred eighty-two patients with CP (n = 176) and RAP (n = 206) and 251 controls were evaluated. Platelet-derived growth factor [beta] polymorphisms +286 A/G (rs#1800818) seen in 5'-UTR and +1135 A/C (rs#1800817) in first intron were genotyped using single-nucleotide polymorphism polymerase chain reaction approach and confirmed by DNA sequencing.

Results: The genotypic frequencies for PDGF-[beta] polymorphisms in positions +286 and +1135 were found to be similar in controls and patients with RAP and CP. There was no difference in genotypic frequencies among RAP, CP, and controls in subjects in the alcohol and smoking subgroups.

Conclusions: Known variations in the PDGF-[beta] gene do not have a significant effect on promoting or preventing fibrogenesis in pancreatitis. Further evaluation of this important pathway is warranted.

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Figures

Figure 1
Figure 1
Figure 1a: Genotype distribution +286 A/G polymorphism among RAP and CP patients and controls RAP, Recurrent acute pancreatitis. CP, Chronic pancreatitis. Figure 1b: Genotype distribution +1135 A/C polymorphism among RAP and CP patients and controls RAP, Recurrent acute pancreatitis. CP, Chronic pancreatitis.
Figure 1
Figure 1
Figure 1a: Genotype distribution +286 A/G polymorphism among RAP and CP patients and controls RAP, Recurrent acute pancreatitis. CP, Chronic pancreatitis. Figure 1b: Genotype distribution +1135 A/C polymorphism among RAP and CP patients and controls RAP, Recurrent acute pancreatitis. CP, Chronic pancreatitis.
See this image and copyright information in PMC

References

    1. Witt H, Apte MV, Keim V, et al. Chronic pancreatitis: challenges and advances in pathogenesis, genetics, diagnosis, and therapy. Gastroenterology. 2007 Apr;132(4):1557–1573. - PubMed
    1. Kloppel G, Maillet B. Chronic pancreatitis: evolution of the disease. Hepatogastroenterology. 1991 Oct;38(5):408–412. - PubMed
    1. Ammann RW, Muellhaupt B, Meyenberger C, et al. Alcoholic nonprogressivechronic pancreatitis: prospective long-term study of a large cohort with alcoholic acute pancreatitis (1976–1992) Pancreas. 1994 May;9(3):365–373. - PubMed
    1. Whitcomb DC. Mechanisms of disease: Advances in understanding the mechanisms leading to chronic pancreatitis. Nat Clin Pract Gastroenterol Hepatol. 2004 Nov;1(1):46–52. - PubMed
    1. Apte MV, Haber PS, Applegate TL, et al. Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture. Gut. 1998 Jul;43(1):128–133. - PMC - PubMed

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