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. 2010 Sep 28;103(7):1089-92.
doi: 10.1038/sj.bjc.6605842. Epub 2010 Aug 17.

Insulin-like growth factors and liver cancer risk in male smokers

J M Major  1 , R Z Stolzenberg-Solomon, M N Pollak, K Snyder, J Virtamo, D Albanes
Affiliations

Insulin-like growth factors and liver cancer risk in male smokers

J M Major et al. Br J Cancer. .

Abstract

Background: The liver is the primary source of circulating insulin-like growth factor (IGF)-I, yet the relation between IGFs and liver cancer is uncertain.

Methods: In a case-cohort study within a cohort of 29,133 male smokers we examined associations of serum IGF-I and IGF binding protein (IGFBP)-3 with liver cancer (50 cases).

Results: Nonlinear associations between liver cancer and IGF-I and IGFBP-3 were observed (P=0.04 and P<0.01, respectively), strongest association at lowest levels (odds ratio (OR)=0.2, 95% confidence interval (CI)=0.1-0.7 for 80 vs 30 ng ml(-1) of IGF-I; OR=0.2, 95% CI=0.1-0.6 for 1400 vs 700 ng ml(-1) of IGFBP-3).

Conclusions: Low IGF-I and IGFBP-3 levels in male smokers are associated with increased risk of liver cancer.

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