Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2010 Nov;30(11):1817-20.
doi: 10.1038/jcbfm.2010.140. Epub 2010 Aug 18.

Predictive value of platelet activation for the rate of cognitive decline in Alzheimer's disease patients

Konstantinos Stellos  1 , Victoria Panagiota, Andreas Kögel, Thomas Leyhe, Meinrad Gawaz, Christoph Laske
Affiliations
Comparative Study

Predictive value of platelet activation for the rate of cognitive decline in Alzheimer's disease patients

Konstantinos Stellos et al. J Cereb Blood Flow Metab. 2010 Nov.

Abstract

Vascular risk factors contribute to the progression of dementia in Alzheimer's disease (AD) and influence platelet activation. However, the degree of platelet activation as a possible underlying mechanism of this progression has not been studied till now. Significantly higher baseline expression of both platelet activation biomarkers, activated glycoprotein IIb-IIIa complex and P-selectin, was observed in patients with AD with fast cognitive decline compared with AD patients with slow cognitive decline during a 1-year follow-up period. These results suggest that platelet activation could be a putative prognostic biomarker for the rate of cognitive decline and a potential new treatment target in AD patients.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Platelet activation associates with cognitive decline in Alzheimer's disease (AD). (A) Box plot showing platelet GPIIb–IIIa complex activation and P-selectin expression levels in AD patients with fast versus slow cognitive decline defined after a 1-year follow-up period. (B) Correlation between change of MMSE score (one year after baseline) and platelet GPIIb–IIIa activation (n=40; r=−0.573; P<0.001) and P-selectin expression (n=40; r=−0.411; P=0.009) in AD patients. (C) Receiver operating characteristic curve for platelet GPIIb–IIIa activation and P-selectin expression for fast cognitive decline after 1-year follow-up in AD patients. GPIIb–IIIa, glycoprotein IIb–IIIa; MMSE, Mini-Mental State Examination.
See this image and copyright information in PMC

References

    1. Akiyama H, Barger S, Barnum S, Bradt B, Bauer J, Cole GM, Cooper NR, Eikelenboom P, Emmerling M, Fiebich BL, Finch CE, Frautschy S, Griffin WS, Hampel H, Hull M, Landreth G, Lue L, Mrak R, Mackenzie IR, McGeer PL, O'Banion MK, Pachter J, Pasinetti G, Plata-Salaman C, Rogers J, Rydel R, Shen Y, Streit W, Strohmeyer R, Tooyoma I, Van Muiswinkel FL, Veerhuis R, Walker D, Webster S, Wegrzyniak B, Wenk G, Wyss-Coray T. Inflammation and Alzheimer's disease. Neurobiol Aging. 2000;21:383–421. - PMC - PubMed
    1. Baskin F, Rosenberg RN, Iyer L, Hynan L, Cullum CM. Platelet APP isoform ratios correlate with declining cognition in AD. Neurology. 2000;54:1907–1909. - PubMed
    1. Carcaillon L, Pérès K, Péré JJ, Helmer C, Orgogozo JM, Dartigues JF. Fast cognitive decline at the time of dementia diagnosis: a major prognostic factor for survival in the community. Dement Geriatr Cogn Disord. 2007;23:439–445. - PubMed
    1. Claassen JA, Diaz-Arrastia R, Martin-Cook K, Levine BD, Zhang R. Altered cerebral hemodynamics in early Alzheimer disease: a pilot study using transcranial Doppler. J Alzheimers Dis. 2009;17:621–629. - PMC - PubMed
    1. Clark CM, Sheppard L, Fillenbaum GG, Galasko D, Morris JC, Koss E, Mohs R, Heyman A. Variability in annual Mini-Mental State Examination score in patients with probable Alzheimer disease: a clinical perspective of data from the Consortium to Establish a Registry for Alzheimer's Disease. Arch Neurol. 1999;56:857–862. - PubMed

Publication types