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. 2010 Oct 4;5(10):1781-7.
doi: 10.1002/cmdc.201000161.

Synthesis of fatty acid amides of catechol metabolites that exhibit antiobesity properties

Bruno Almeida  1 , Jesús Joglar, María Jesús Luque Rojas, Juan Manuel Decara, Francisco Javier Bermúdez-Silva, Manuel Macias-González, Montserrat Fitó, Miguel Romero-Cuevas, Magí Farré, María Isabel Covas, Fernando Rodríguez de Fonseca, Rafael de la Torre
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Synthesis of fatty acid amides of catechol metabolites that exhibit antiobesity properties

Bruno Almeida et al. ChemMedChem. .

Abstract

A series of fatty acid amides of 3,4-methylenedioxymethamphetamine (MDMA) catechol metabolites were synthesized in order to evaluate their biological activities. Upon administration, all synthesized compounds resulted in negative modulation of food intake in rats. The most active compounds have affinity for the CB(1) receptor and/or PPAR-α; part of their biological activity may be caused by these double interactions.

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